Bioerodible polyanhydrides for controlled drug delivery

Initial in vitro and in vivo (rat) studies using a poly(anhydride), poly[bis(p-carboxyphenoxy)methane], as a bioerodible matrix for controlled drug delivery are described. Drug delivery matrices fabricated from this material and containing cholic acid showed a period of nearly zero-order erosion kinetics during which this steroid was released at nearly the same constant rate.